Visiting Lindenwood scored three goals in a span of 6:30 of the second half on the way to a 4-1 win over the Tigers. The Lions added a fourth with 2:56 remaining.
Margaret McDermott scored the Tigers' lone goal with 1:02 left.
Lindenwood outshot the Tigers 22-9 and the Tigers held a 10-6 advantage in corners.
DePauw fell to 3-2 on the season with the defeat. The Tigers return to action on Saturday, September 13 at Bellarmine.